Editorial| Volume 11, ISSUE 2, P47-48, April 2022

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Muscle-bone crosstalk by organokines—the new “hope molecules”

      Organ crosstalk, the unique and sophisticated method of cell-cell and organ-to-organ communication, is essential for maintaining multiple physiologic functions and regulating metabolic pathways. It is now recognized that, apart from receiving endocrine signals through growth hormones, growth factors, and the like, muscles, bone, and other tissues can secrete biochemical signals by their cells facilitating the metabolism of its tissues and the whole body. These molecules are known as “organokines” in general and depending on their tissue of origin, they are named adipokines, hepatokines, batokines, osteokines, and myokines. Research data reveals that the organokines are essential for maintaining whole-body metabolism through autocrine, paracrine, and endocrine pathways and can be used as valuable biomarkers for monitoring various organs’ physiologic and metabolic responses to mechanical loading.
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        • Severinsen MCK
        • Pedersen BK
        Muscle–organ crosstalk: the emerging roles of myokines [published correction appears in Endocr Rev 2021;42:97–9].
        Endocr Rev. 2020; 41: 594-609
        • Kirk B
        • Feehan J
        • Lombardi G
        • Duque G.
        Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines.
        Curr Osteoporos Rep. 2020; 18: 388-400
        • Chowdhury S
        • Schulz L
        • Palmisano B
        • et al.
        Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts.
        J Clin Invest. 2020; 130: 2888-2902
        • Buvinic S
        • Balanta-Melo J
        • Kupczik K
        • Vásquez W
        • Beato C
        • Toro-Ibacache V.
        Muscle-bone crosstalk in the masticatory system: from biomechanical to molecular interactions.
        Front Endocrinol (Lausanne). 2021; 11606947