Organ crosstalk, the unique and sophisticated method of cell-cell and organ-to-organ
communication, is essential for maintaining multiple physiologic functions and regulating
metabolic pathways. It is now recognized that, apart from receiving endocrine signals
through growth hormones, growth factors, and the like, muscles, bone, and other tissues
can secrete biochemical signals by their cells facilitating the metabolism of its
tissues and the whole body. These molecules are known as “organokines” in general
and depending on their tissue of origin, they are named adipokines, hepatokines, batokines,
osteokines, and myokines. Research data reveals that the organokines are essential
for maintaining whole-body metabolism through autocrine, paracrine, and endocrine
pathways and can be used as valuable biomarkers for monitoring various organs’ physiologic
and metabolic responses to mechanical loading.
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References
- Muscle–organ crosstalk: the emerging roles of myokines [published correction appears in Endocr Rev 2021;42:97–9].Endocr Rev. 2020; 41: 594-609
- Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines.Curr Osteoporos Rep. 2020; 18: 388-400
- Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts.J Clin Invest. 2020; 130: 2888-2902
- Muscle-bone crosstalk in the masticatory system: from biomechanical to molecular interactions.Front Endocrinol (Lausanne). 2021; 11606947
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© 2022 World Federation of Orthodontists. Published by Elsevier Inc. All rights reserved.
