Multilevel biological responses following piezocision to accelerate orthodontic tooth movement: A study in rats

  • Carole Charavet
    Correspondence
    Corresponding author: Service d’Orthodontie et Orthopédie Dento-Faciale, Quai Godefroid Kurth 45, Polyclinique Brull, B-4020 Liège, Belgium.
    Affiliations
    Department of Orthodontics and DentoFacial Orthopedics, University Hospital of Liège, Dental Biomaterials Research Unit, Faculty of Medicine, University of Liège, Belgium
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  • Dorien Van Hede
    Affiliations
    Department of Periodontology and Oral Surgery, University Hospital of Liège, Dental Biomaterials Research Unit, Faculty of Medicine, University of Liège, Belgium
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  • Sandy Anania
    Affiliations
    Department of Periodontology and Oral Surgery, University Hospital of Liège, Dental Biomaterials Research Unit, University Hospital of Liège, Belgium
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  • Nathalie Maes
    Affiliations
    Biostatistics and Medico-Economic Information Department, University Hospital of Liège, Belgium
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  • France Lambert
    Affiliations
    Department of Periodontology and Oral Surgery, University Hospital of Liège, Dental Biomaterials Research Unit, Faculty of Medicine, University of Liège, Belgium
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Published:August 06, 2019DOI:https://doi.org/10.1016/j.ejwf.2019.07.002

      Abstract

      Aim

      The objective of the present study was to explore the alveolar bone tissue response and its dynamic at the tissue, cellular, and molecular levels following a piezocision procedure in a rat model.

      Methods

      Sixty rats were randomly allocated to either a control group (conventional orthodontic tooth movement) (TM) or a test group (piezocision-assisted orthodontic tooth movement) (TM+PS). Tissue, cellular, and molecular analyses were performed at 7, 28, and 42 days after the procedures. Orthodontic Tooth Movement (OTM) and Bone Volume Fraction (BVF) were evaluated using Nano-computed tomography. Moreover, histological parameters such as the number of osteoclasts were assessed, and the expression of cytokines involved in the bone turnover was investigated using quantitative reverse transcriptase polymerase chain reaction analysis.

      Results

      The OTM was 1.8 times faster in the TM+PS compared with the TM at day 42. A significant decrease in BVF was found in the TM+PS group compared with the TM group at day 7 and day 28, whereas no difference was observed at day 42. The number of osteoclasts was significantly higher in the TM+PS group compared with the TM group at day 7. No difference between the two groups was found in the number of osteoclasts involved in root resorption. RANKL and osteoprotegerin were significantly higher in the piezocision group than in the control group at day 7.

      Conclusions

      In these conditions, the efficacy of piezocision-assisted alveolar decortication to accelerate tooth movement was demonstrated, and the underlying biological responses at the tissue, cellular and molecular levels were emphasized.

      Keywords

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